Nowadays, airborne disease is one of the most killer diseases, in particular among a high urban population and uncontrolled movement activities of low socio-economic communities. Most local health departments in poor developing countries have difficulty in fully applying geospatial technology for local agencies due to high-cost and technical skills. This study demonstrates the ways to develop a low-cost and minimal-skill disease system for the local health government sector using the ArcGIS solution platform in Selangor, Malaysia. Features and functions of ArcGIS such as ArcGIS Pro, ArcGIS Online and Web Apps were explored for the disease mapping, data analysis and system development. By focusing on tuberculosis (TB) cases as examples, the result showed that a TB monitoring system was developed by fulfilling the user requirements. The system displays the database and mapping of the cases and spatially analyses the cases. A geospatial solution platform, mainly ArcGIS could assist the local organisations in managing the disease datasets in a systematic way.