Respiratory diseases such as hypoxemia or infections caused by viruses such as coronavirus disease 2019 (COVID-19) cause the patient's oxygen saturation (SpO2) to drop dramatically. SpO2 below average values (< 90%) can cause organ dysfunction and even death. To prevent this, the patient must be given supplementary oxygen for a specific duration and observe the patient's SpO2 changes during the oxygen therapy. Based on these problems, a solution can be offered by utilizing digital technology to integrate medical products such as oxygen concentrators (Oxycon), oximeters, etc., which a doctor can monitor remotely (telemedicine); therefore, the doctor can decide the treatment time accurately by autopilot integrated system. This study aimed to design a system for SpO2 therapy to monitor the patient who uses a mobile oxygen concentrator integrated with a smartphone application and facilitates lung specialists to control the patient's progress. In this study, a prototype of Oxycon was made, which produced a concentration of oxygen up to 95% stably during the treatment, which can be remotely controlled and integrated with telemetry communication and telemedicine applications that can operate according to the needs of lung specialists. Determination of the therapy time parameter determines the success of the SpO2 therapy process to avoid the adverse effects of excess oxygen entering the body.